Bayer: 5 key drugs to have combined peak sales of 5.5 billion euro
















LEVERKUSEN, Germany (Reuters) – Bayer said its five most promising new drugs have an annual peak sales potential of more than 5.5 billion euros ($ 7 billion).


The sales forecast comprises anti-clotting pill Xarelto, ophthalmic drug Eylea, also calle VEGF Trap-Eye, anti-cancer products Alpharadin and Stivarga, as well as lung treatment riociguat.













Last year, Bayer said four of the drugs, excluding riociguat, would have a peak sales potential of more than 5 billion euros.


(Reporting by Frank Siebelt; Writing by Ludwig Burger)


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Glitch prevents trading in over 200 stocks on the NYSE
















NEW YORK (Reuters) – NYSE Euronext on Monday suspended trading in over 200 stocks on the New York Stock Exchange due to a technical problem with a server, though the stocks in question were still trading actively on other markets.


There will be no closing auctions in the affected stocks, and a list of the official closing prices for the securities, based on the consolidated last sale, will be distributed via email and NYSE’s website, the exchange operator said.













NYSE first alerted traders it was having problems with one of its cash equity matching engines at 9:38 a.m., and it said it would not publish quotes on a total of 216 stocks, including CVS Caremark Corp and Lazard Ltd .


Nasdaq OMX Group , BATS Global Markets and Direct Edge exchanges stopped sending orders to the NYSE, declaring “self help” against the exchange.


“Orders were coming in, but those who were issuing the orders were not getting their confirmations or their reports, so we felt it was best to zero it out, if you will, and then to suspend trading of those stocks on our market,” said Rich Adamonis, an NYSE spokesman.


NYSE said that any open orders should be considered canceled.


Adamonis said the server issues were still being investigated at around 3 p.m., but said they came as the issues were being moved over to a new trading platform.


NYSE is in the process of moving all of its markets – including bonds, options, futures and cash equities – in the United States and Europe to a universal electronic trading platform.


The New York-based company’s European markets have been fully integrated with the new system, and the exchange is now in the process of moving over its roughly 3,800 U.S. cash equities issues to the new platform, with about 800 having been migrated so far, Adamonis said.


The migration will continue to be rolled out through the rest of the year, he added.


(Reporting By John McCrank; Editing by Leslie Adler)


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Belize wants to quiz anti-computer virus guru McAfee in murder probe
















BELIZE CITY (Reuters) – Police in Belize want to question U.S. anti-computer virus software pioneer John McAfee in connection with the murder of a neighbor he had been quarrelling with, but they say he remains a person of interest at this time and is not a suspect.


McAfee, who invented the anti-virus software that bears his name, has homes and businesses in Belize, and is believed to have settled in the country sometime around 2010.













“He is a person of interest at this time,” said Marco Vidal, head of Belize’s police Gang Suppression Unit. “It goes a bit beyond that, not just being a neighbor.”


Police officers were looking for the software engineer, said Miguel Segura, the assistant commissioner of police.


Asked if McAfee was a suspect, he said: “At this point, no. Our job … is to get all the evidence beyond reasonable doubt that Mr A is the one that killed Mr B.”


“He (McAfee) … can assist the investigation, so there is no arrest warrant for the fellow,” added Segura, who heads the Criminal Investigation Branch.


McAfee’s neighbor, Gregory Viant Faull, a 52-year-old American, was found on Sunday lying dead in a pool of blood after apparently being shot in the head.


McAfee has been embroiled in controversy in Belize before.


His premises were raided in May after he was accused of holding firearms, though most were found to be licensed. The final outcome of the case is pending.


McAfee also owns a security company in Belize as well as several properties and an ecological enterprise.


Reuters was unable to contact McAfee on Monday.


Segura said McAfee had been at odds with Faull for some time. He accused his neighbor of poisoning his dogs earlier this year and filed an official complaint.


“There was some conflict there between (them) … prior to the death of the gentleman,” Segura said. “But those dogs didn’t have a post mortem to see if the toxicology would confirm what type of poison, if any.”


McAfee previously accused the police Gang Suppression Unit of killing his dogs during the May raid.


McAfee was one of Silicon Valley’s first entrepreneurs to amass a fortune by building a business off the Internet.


The former Lockheed systems consultant started McAfee Associates in 1989, initially distributing its anti-virus software as “shareware” on Internet bulletin boards.


He took the company public in 1992 and left two years later following accusations that he had hyped the arrival of a virus known as Michelango, which turned out to be a dud, to scare computer users into buying his company’s products.


(Reporting by Simon Gardner and Gabriel Stargardter in Mexico City and Jim Finkle; Editing by Kieran Murray and Todd Eastham)


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Australia’s INXS calls it quits as touring band after 35 years
















SYDNEY (Reuters) – Australian rock group INXS has called it quits as a live touring band after 35 years, thanking fans and honoring late frontman Michael Hutchence in a statement on Tuesday.


INXS, which sold more than 30 million albums worldwide, including more than 10 million alone of their 1987 breakthrough “Kick”, issued the statement after comments by band member Jon Farriss during a weekend performance sparked a frenzy on Twitter.













“We understand that this must come as a blow to everybody, but all things must eventually come to an end,” INXS members Tim, Andrew and Jon Farriss, Kirk Pengilly and Garry Beers said. “We have been performing as a band for 35 years, it’s time to step away from the touring arena.”


“Our music will of course live on and we will always be a part of that,” they added.


INXS was one of the biggest touring bands of the 1980s and 1990s, playing to 80,000 at Wembley Stadium in London and 120,000 in Rio De Janeiro.


But the death of charismatic lead singer Hutchence in 1997 was a major blow.


A U.S. TV talent show for a new frontman was won by Canadian J.D. Fortune, while Terence Trent D’Arby and Jon Stevens also had a turn at the microphone. Irishman Ciaran Gribbin was the last to take the role.


Farriss, the band’s drummer, set the Internet abuzz on Sunday night after he told the audience during a support performance for U.S. band Matchbox Twenty in Perth that it was the last time INXS would perform together. Saxophone player Pengilly later told a radio station the band was not breaking up.


The group declined to comment further on Tuesday.


(Reporting By Grace Williams, editing by Elaine Lies)


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Arseus makes three acquisitions, sees more this year
















BRUSSELS (Reuters) – Belgo-Dutch medical supplies firm Arseus has made three acquisitions in drug compounding and plans to announce more by the end of the year as it seeks to benefit from a growing trend of pharmacists mixing their own medicines.


The firm, which also sells dentist chairs and surgical equipment, said on Tuesday it has made acquisitions in Brazil, Colombia and Scandinavia worth around 16.5 million euros ($ 21 million) in total.













The firm is the only real global company that supplies ingredients for compounding, meaning it has become the consolidator in the sector.


“There are lots of opportunities and we are involved in numerous processes now, so we hope to announce a little bit more before the end of the year,” Chief Executive Ger van Jeveren told Reuters in a telephone interview.


He said the company has 75 million euros in cash that is still available for acquisitions.


Arseus said the three added companies would generate a combined annual revenue of 12 million euros, with a 25 percent core profit margin.


The acquisitions are to be consolidated from Nov 1. ($ 1 = 0.7867 euros)


(Reporting By Ben Deighton; editing by Philip Blenkinsop)


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Oil drifts as fiscal cliff looms over US economy
















BANGKOK (AP) — Oil prices drifted Monday as traders worried about the threat to the U.S. economy if lawmakers and President Barack Obama don’t reach an agreement to avoid automatic tax hikes and spending cuts.


Benchmark crude for December delivery was down 23 cents to $ 85.84 a barrel at late afternoon Bangkok time in electronic trading on the New York Mercantile Exchange. The contract rose 98 cents to finish at $ 86.07 per barrel on the Nymex on Friday.













Obama and congressional leaders face a Jan. 2 deadline to reach an agreement or at least come up with a framework to deal with expiring Bush-era tax cuts and automatic spending cuts to defense and domestic programs — known as the “fiscal cliff.”


Economists say the cuts could total $ 800 billion, cost 3 million jobs and plunge the U.S. back into recession. Analysts say more stock market turmoil could arise as the deadline approaches.


Obama was to begin talking to lawmakers in Washington this week on a deal.


Brent crude, used to price international varieties of oil, fell 48 cents to $ 108.92 a barrel on the ICE Futures exchange in London.


Among other energy futures trading on Nymex:


— Heating oil fell 0.6 cent to $ 3.00 a gallon.


— Wholesale gasoline rose 0.2 cent to $ 2.66 a gallon.


— Natural gas fell 1.8 cents to $ 3.485 per 1,000 cubic feet.


___


Follow Pamela Sampson on Twitter at http://twitter.com/pamelasampson.


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Top 5 Apps Your Kids Will Love This Week
















Chris Crowell is a veteran kindergarten teacher and contributing editor to Children’s Technology Review, a web-based archive of articles and reviews on apps, technology toys and video games. Download a free issue of CTR here.


[More from Mashable: 4 Tips for Finding a Job in Your Niche]













Spot the Dot


$ 3.99 Ages 3-up Overall rating: 4.8 out of 5 stars Why we like it: Spot the Dot turns a children’s book into a lively, engaging experience. Based on the book by David Carter, Spot the Dot is a “needle in the haystack” or “I Spy” type of app, where the same item — a small colored dot, is hidden in nine screens. Need to know: On some pages the dot is hidden in a moving illustration, and the dot moves around, extending the utility of this app, despite the limited number of pages. This is a great app for a group of children to play together. Ease of use: 9/10 Educational: 10/10 Entertaining: 9/10


Click here to view this gallery.


[More from Mashable: Scientists Use Their Braaaaains to Find Perfect Product Tester [SUNDAY COMICS]]


If you’re getting in the mood for the holiday season, A Charlie Brown Christmas is one app that both kids and nostalgic parents are sure to enjoy. And while you’re sharing, why not stretch your brain and see if you remember those isosceles triangles and quadrilaterals as well as your kids do. Those are just some of the apps in store for you this week!


The folks at Children’s Technology Review shared with us these five top apps from their comprehensive monthly database of kid-tested reviews. The site covers everything from math and counting to reading and phonics.


Check back next week for more Top Kids Apps from Children’s Technology Review.


This story originally published on Mashable here.


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Laughing in the storm: Comics don’t shy from Sandy
















NEW YORK (AP) — Comedian Dave Attell told a packed house at the Comedy Cellar that New York after Superstorm Sandy had a familiar feel. “It was dark. Toilets were backing up. … It was pretty much like it always was.”


Another comic, Paul Mecurio, told the same crowd that he got so many calls from worried family members that he started making things up about how bad it was.













“I’m drinking my own urine to survive,” he joked.


New York’s comedy clubs, some of which had to shut down or go on generator power in the aftermath of the storm, dealt with a bad situation like they always have — by turning Sandy into a running punchline.


“If they’re going to do jokes on Sept. 12 about Sept. 11, then this thing isn’t going to slow us down,” said Vic Henley, the emcee of a show Oct. 28 at Gotham Comedy Club.


Sean Flynn, Gotham’s operating manager, said comics were including the storm in their acts but had to be careful nonetheless not to make people feel worse than they already did.


“There’s the old adage that tragedy plus time equals comedy. The variable is the time,” he said. Still, he added: “You can’t ignore the subject. That’s what comedy’s all about.”


The Comedy Cellar, a regular stop for decades for the country’s most notable comedians, was closed from Oct. 28 through Nov. 1, but reopened on Nov. 2 after a generator was brought in at a cost of several thousand dollars. Power didn’t return until the next day, and the crowds came with it.


Everyone has a bad case of cabin fever,” said Valerie Scott, the club’s manager.


Mecurio said he thought the joke was on him when he got a call from the Comedy Cellar saying the club was going ahead with its show even though there was no light in the West Village. He headed downtown from the Upper East Side, hitting dark streets after midtown.


“It’s pitch dark,” he said. “And there’s a room packed with people laughing. It was so surreal. … I’m calling it the generator show. It was a really cool thing.”


“You could feel there was something special about the show,” he said. “The audiences were tempered in their mood. You could tell something was up, something was in the air. I knew it was cathartic for people.”


He said a woman approached him after the show to thank him, saying: “You kind of brightened my day.”


Sometimes, comics used the storm to get a laugh at the expense of the crowd, like when Mark Normand looked down from the Comedy Cellar stage at a man with a thin beard.


“I like the beard,” he told him. “Is that because of Sandy? You couldn’t get your razor working?”


And Attell used Sandy to mock a heckler, telling him: “You must have been a load of laughs without power.”


At another point, Attell looked for positives in the storm.


“There’s nothing better than Doomsday sex,” he said.


Mecurio said he has made a point of including the storm and the havoc it caused whenever he takes the stage.


“I feel like as a comedian in the spirit of social satire, it’s what we’re supposed to do,” he said. “It’s the elephant in the room. How do you not do it?”


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More than one U.S. soldier shot Afghans, says local investigator
















TACOMA (Reuters) – A shooting rampage in March that left 16 Afghans dead in two villages was the work of more than one person, an Afghan police investigator testified on Sunday, contradicting the U.S. government’s account.


Military prosecutors are seeking the death penalty for Army Staff Sergeant Robert Bales, accusing him of killing the villagers, mostly women and children, when he ventured out of his remote camp on two revenge-fueled forays over a five-hour period in March.













The government believes Bales was solely responsible for the deaths, and survivors have testified to seeing only a single soldier. But several indirect accounts have suggested that more than one U.S. soldier was involved.


“One person did not have the courage to go to the villages in the dark of night,” Major Khudai Dad, the Afghan Uniform Police’s chief of criminal techniques in Kandahar City, told a hearing at a U.S. Army base via video link from Kandahar.


“There’s no way it is one person,” said Dad, speaking through an interpreter. Dad visited three compounds several thousand meters apart in the villages of Alkozai and Najiban around 8 a.m. on March 11, hours after the attacks.


“One person cannot do this work,” said Dad, adding that he spent only one hour at the three compounds, fearing Taliban attacks.


Dad was the sole witness on the seventh day of testimony before an ‘Article 32′ hearing at Joint Base Lewis-McChord in Washington state, which will establish whether Bales will face a court martial and possible death penalty if found guilty.


The shootings in Kandahar province marked the worst case of civilian slaughter blamed on an individual U.S. soldier since the Vietnam War and damaged already strained U.S.-Afghan relations.


SECOND SHOOTER THEORY


On Saturday, a U.S. investigator told the hearing that the wife of one of the victims told her during questioning in June that she saw more than one soldier on the night in question.


Army criminal investigator Leona Mansapit said the wife of Mohamed Dawood, who was killed in the village of Najiban, recalled a gunman entering the couple’s room shouting about the Taliban, while another man, a U.S. soldier, stood at the door.


This woman was persuaded by male family members not to testify to the hearing, an Army source, who asked not to be named, said on Sunday.


Dad said he took bullet shells from three different compounds, which were several kilometers apart, and turned them over to the Afghan National Army, who passed them on to U.S. investigators.


“In those three areas, where the incidents were, I was thinking and I’m thinking that is not a thing that one person would do,” he said.


A veteran of four combat tours in Iraq and Afghanistan, Bales faces 16 counts of premeditated murder and six counts of attempted murder, as well as charges of assault and wrongfully possessing and using steroids and alcohol while deployed.


Prosecutors have already presented physical evidence to tie Bales to the crime scene, with a forensic investigator saying a sample of blood on his clothing matched a swab taken in one of the compounds where the shooting occurred.


Bales’ lawyers have not set out an alternative theory to the prosecution case, but have pointed out inconsistencies in testimony and highlighted incidents before the shooting in which Bales lost his temper easily, possibly setting up an argument that he was suffering from post-traumatic stress disorder.


Gathering evidence and witness statements was complicated by the speedy burial of victims, the inability of U.S. investigators to access the crime scenes for three weeks after the violence, and the dispersal of possible witnesses after treatment at a Kandahar hospital.


(Reporting By Laura L. Myers, writing by Bill Rigby; Editing by John Stonestreet)


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China slams “distorted” view of copyright piracy problem
















BEIJING (Reuters) – China‘s top official in charge of fighting copyright piracy on Sunday slammed what he said was deliberate distortion of the problem by the Western media caused by the country’s poor global image, saying important facts had been ignored.


Foreign governments, including the United States, have for years urged China to take a stronger stand against pervasive violations of intellectual property rights on products ranging from medicines to software to DVD movies sold on the street.













The United States in April again put China, along with Russia, on its annual list of countries with the worst records of preventing the theft of copyrighted material and other intellectual property.


But Tian Lipu, head of China’s State Intellectual Property Office, said the government’s efforts were being ignored.


“Speaking honestly, there is a market. People use and buy pirated goods,” Tian told reporters on the sidelines of a landmark Communist Party congress.


“To a large extent, China’s intellectual property rights protection image has been distorted by Western media.


“China’s image overseas is very poor. As soon as people hear China they think or piracy and counterfeiting — (Beijing’s) Sanlitun, that place in Shanghai, Luohu in Shenzhen,” he said, referring to places notorious for selling fake goods.


“We don’t deny (this problem), and we are continuing to battle against it,” Tian added.


But other facts were overlooked, he said.


“For example, China is the world’s largest payer for patent rights, for trademark rights, for royalties, and one of the largest for buying real software,” he said. “We pay the most. People rarely talk about this, but it really is a fact. Our government offices, our banks, our insurance companies, our firms … the software is all real.”


Microsoft Corp and other members of the Business Software Alliance in the United States complain that nearly 80 percent of the software installed on personal computers in China is pirated.


Tian said that if companies like Apple Inc were so worried by piracy they would never choose China for their production bases.


“Of the goods made for Apple, most are made in China. Once Apple’s brand is added to it and it is exported to the United States its value doubles,” he said.


“This could only happen because China’s intellectual property rights environment sets foreign investors at ease allowing them to come to China to manufacture.”


The International Intellectual Property Alliance, a U.S. coalition of film, software, music and publishing groups, estimates that U.S. companies lost more than $ 15 billion in 2009 due to international copyright theft.


About $ 14 billion of the total was due to software piracy, with an estimated $ 3.5 billion in losses in China and $ 1.4 billion in Russia.


(Editing by Ron Popeski)


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